Age directly correlated with percent maximum atrial fragmentation (r=0.32, P<0.05) and effective refractory period (r=0.45, P<0.001), but not with wavelength index or AF inducibility.
Cross-Sectional (n=45)
Aging is associated with increased atrial fragmentation and prolonged effective refractory period, but not with wavelength index or AF inducibility in patients without prior AF, suggesting different AF triggers in younger versus older patients.
Estimación del efecto: r = 0.45
valor p: p=<0.001
Although atrial fibrillation is a common arrhythmia, especially in the elderly, little is known about age-related changes in the electrophysiologic properties of the atrium. The aim of this study was to analyze the effect of aging on atrial vulnerability to atrial fibrillation. An electrophysiologic study was performed in 45 patients with no history of atrial fibrillation, Wolff-Parkinson-White syndrome, structural heart disease, or conditions with potential effects on cardiac hemodynamic or electrophysiologic function (15 females; mean age, 52 +/- 18 years; range, 14 to 84 years). The following atrial excitability parameters were assessed: spontaneous or paced (A1) and extrastimulated (A2) atrial electrogram widths, percent maximum atrial fragmentation (A2/A1 x 100), effective refractory period, wavelength index (ERP/A2), and inducibility of atrial fibrillation. Atrial fibrillation was induced in 9 patients. Percent maximum atrial fragmentation was greater (176 +/- 36 vs 137 +/- 26%, P < 0.001) and wavelength index was shorter (2.4 +/- 0.4 vs 3.2 +/- 0.9, P < 0.01) in the patients with than without inducible atrial fibrillation. However, age was similar in patients with and without inducible atrial fibrillation (47 +/- 11 vs 53 +/- 19 years, P = 0.36). Percent maximum atrial fragmentation and effective refractory period directly correlated with age (r = 0.32, P < 0.05 and r = 0.45, P < 0.001, respectively). On the other hand, wavelength index (3.1 +/- 0.9) did not correlate with age (r = -0.05, P = 0.77). This study suggests that the mechanism triggering atrial fibrillation may be very well different between older and younger patients with atrial fibrillation, because younger patients have no marked substrate for atrial fibrillation.
Sakabe et al. (Wed,) conducted a cross-sectional in No history of atrial fibrillation (n=45). Electrophysiologic study was evaluated on Correlation of effective refractory period with age (r = 0.45, p=<0.001). Age directly correlated with percent maximum atrial fragmentation (r=0.32, P<0.05) and effective refractory period (r=0.45, P<0.001), but not with wavelength index or AF inducibility.
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