Non-Hispanic Black patients treated with anthracyclines had a significantly higher risk of cardiotoxicity compared to Non-Hispanic White patients (16.3% vs 7.2%; HR 2.62, 95% CI 1.23-5.56).
Cohort (n=743)
Does race/ethnicity affect the risk of cardiotoxicity in adult patients with cancer treated with anthracyclines?
Non-Hispanic Black and Hispanic patients face a significantly higher risk of anthracycline-induced cardiotoxicity compared to Non-Hispanic White patients, independent of baseline cardiovascular risk factors.
Estimación del efecto: HR 2.62 (95% CI 1.23-5.56)
Tasa de eventos absoluta: 16.3% vs 7.2%
valor p: p=0.024
Background Cardiotoxicity in patients with cancer treated with anthracyclines is associated with increased morbidity and mortality. We aimed to examine the incidence of and risk factors for cardiotoxicity in a racially and ethnically diverse cohort with cancer treated with anthracyclines. Methods We included consecutive adult patients who underwent anthracycline‐based chemotherapy from 2016 to 2019 for any type of cancer. The end point was the development of cardiotoxicity (defined as clinical heart failure or drop in left ventricular ejection fraction ≥10% to ≤50%). Results A total of 743 individuals were included (28.0% Non‐Hispanic NH White, 30.5% NH Black, 38.5% Hispanic, 3.0% Asian). Hypertension, diabetes, hyperlipidemia, obesity, and low socioeconomic status were more common in NH Black and Hispanic individuals. During a median follow‐up of 21 months, 98 individuals (13.2%) developed cardiotoxicity. The incidence of cardiotoxicity was significantly higher in NH Black (16.3%), Hispanic (14.7%) and Asian (18.2%) individuals than in NH White (7.2%) individuals ( P =0.024). After adjusting for cardiovascular risk factors, socioeconomic status score, anthracycline dose, baseline left ventricular ejection fraction, and cancer type, being NH Black (hazard ratio HR, 2.62 95% CI, 1.23–5.56) or Hispanic (HR, 2.37 95% CI, 1.11–5.07) was independently associated with a higher risk of cardiotoxicity. NH Black and Hispanic individuals had a greater decline in left ventricular ejection fraction compared with NH White and Asian counterparts. The associations between baseline characteristics and incident cardiotoxicity were similar across different racial and ethnic groups. Conclusions In a large retrospective multiracial and ethnic cohort treated with anthracyclines, NH Black, Hispanic, and Asian individuals had an increased risk of cardiotoxicity compared with their NH White counterparts.
Zhang et al. (Wed,) conducted a cohort in Cancer (n=743). Non-Hispanic Black race/ethnicity vs. Non-Hispanic White race/ethnicity was evaluated on Development of cardiotoxicity (clinical heart failure or drop in left ventricular ejection fraction ≥10% to ≤50%) (HR 2.62, 95% CI 1.23-5.56, p=0.024). Non-Hispanic Black patients treated with anthracyclines had a significantly higher risk of cardiotoxicity compared to Non-Hispanic White patients (16.3% vs 7.2%; HR 2.62, 95% CI 1.23-5.56).