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A Unimolecular G-Quadruplex that Functions as a Synthetic Transmembrane Na+ Transporter | Synapse

December 10, 2005

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A Unimolecular G-Quadruplex that Functions as a Synthetic Transmembrane Na+ Transporter

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Resumen

We describe the covalent post-modification of a hydrogen-bonded assembly with the subsequent formation of a potent transmembrane Na+ ion transporter. Olefin metathesis is used to cross-link all 16 guanosine subunits in a lipophilic G-quadruplex. The resulting unimolecular G-quadruplex folds in the environment of a phospholipid membrane and functions as a Na+ ion transporter as judged by fluorescence and 23Na NMR transport assays.

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Cite This Study

Kaucher et al. (Sat,) studied this question.

synapsesocial.com/papers/6a12b52d5bb7edc7189e2536 https://doi.org/https://doi.org/10.1021/ja056888e

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1Diffusion NMR Spectroscopy in Supramolecular and Combinatorial Chemistry: An Old Parameter—New Insights2004 · 1,101 citations
2Toward Artificial Ion Channels: A Lipophilic G-Quadruplex2000 · 235 citations
3Pyranine as a sensitive pH probe for liposome interiors and surfaces. pH gradients across phospholipid vesicles1978 · 356 citations
4Formation of a Hydrogen-Bonded Receptor Assembly in Niosomal Membranes2004 · 23 citations
5Synthesis and Activity of a New Generation of Ruthenium-Based Olefin Metathesis Catalysts Coordinated with 1,3-Dimesityl-4,5-dihydroimidazol-2-ylidene Ligands1999 · 3,422 citations