What is the clinical evidence from this study?

Study design: Cohort. Population: Mortality (n=59636). Intervention: Physical activity vs. No physical activity. Primary outcome: All-cause death (men) (HR 0.68, 95% CI 0.60-0.76).

What does this research mean for the field?

Physical activity is associated with a lower risk of all-cause death in both men and women, as well as a lower risk of cancer death in men, compared to those who do not exercise. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

January 1, 2012Open Access

Physical Activity Level and Risk of Death: The Severance Cohort Study

Resultado clave

Physical activity was associated with a lower risk of all-cause death in both men (HR 0.68; 95% CI 0.60-0.76) and women (HR 0.65; 95% CI 0.53-0.79) compared to those who did not exercise.

Diseño del estudio

Tipo

Cohort (n=59,636)

Multicéntrico

PICO estructurado

Does physical activity reduce the risk of all-cause death, cancer death, and noncancer death in Korean adults?

Población

59,636 Korean adults aged 30 to 93 years without pre-existing cancer, cardiovascular disease, lung disease, or asthma at baseline.

Intervención

Physical activity (categorized as 3.5-1000 or >1000 MET-min/week based on self-reported leisure activities)

Comparador

No physical activity (0 MET-min/week)

Resultado

Cancer incidence, all-cause death, cancer death, and noncancer deathhard clinical

Self-reported physical activity is associated with a significantly lower risk of all-cause and noncancer mortality in a large Korean cohort.

Resultado numérico

Estimación del efecto: HR 0.68 (95% CI 0.60-0.76)

Resumen

BACKGROUND: Physical activity decreases deaths from cardiovascular disease and other causes; however, it is unclear whether physical activity is associated with cancer incidence and death in Asian populations. METHODS: Data from 59 636 Koreans aged 30 to 93 years were collected using a questionnaire and medical examination at the Severance Hospital Health Promotion Center between 1994 and 2004. Study participants were followed for a mean duration of 10.3 years. RESULTS: In the exercising group, the multivariate Cox proportional hazards model showed a lower risk of cancer death (hazard ratio HR = 0.72, 95% CI = 0.62-0.85) in men but not in women. Those who exercised, as compared with those who did not, had lower risks of all-cause death (men: HR = 0.68, 95% CI = 0.60-0.76; women: HR = 0.65, 95% CI = 0.53-0.79) and noncancer death (men: 0.63, 0.53-0.75; women: 0.52, 0.39-0.69). Physical activity was inversely associated with risk of noncancer death among men and women. CONCLUSIONS: Physical activity was associated with lower risks of cancer death and noncancer death.

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