Prostate Specific Antigen in the Diagnosis and Treatment of Adenocarcinoma of the Prostate. II. Radiation Treated Patients

No AccessJournal of Urology1 May 1989Prostate Specific Antigen in the Diagnosis and Treatment of Adenocarcinoma of the Prostate. II. Radiation Treated Patients Thomas A. Stamey, John N. Kabalin, and Michelle Ferrari Thomas A. StameyThomas A. Stamey More articles by this author , John N. KabalinJohn N. Kabalin More articles by this author , and Michelle FerrariMichelle Ferrari More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)41176-1AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Serum prostate specific antigen was determined (Yang polyclonal radioimmunoassay) in 183 men after radiation therapy for adenocarcinoma of the prostate. A total of 163 men had received 7,000 rad external beam radiotherapy and 20 had been implanted with 125iodine seeds. Only 11 per cent of these 183 patients had undetectable prostate specific antigen levels at a mean interval of 5 years since completion of radiotherapy. Prostate specific antigen levels after radiotherapy were directly related to initial clinical stage and Gleason score before treatment. Multiple prostate specific antigen determinations were performed with time in 124 of 183 patients. During year 1 after radiotherapy prostate specific antigen levels were decreasing in 82 per cent of the patients but only 8 per cent continued to decrease beyond year 1. Of 80 patients observed greater than 1 year after completion of radiotherapy 51 per cent had increasing values and 41 per cent had stable values. Increasing prostate specific antigen values after radiotherapy were correlated with progression to metastastic disease and residual cancer on prostate biopsy. Total serum acid phosphatase levels were poorly related to prostate specific antigen levels, were less effective in discriminating patients with metastatic disease and provided no additional information beyond that provided by prostate specific antigen. © 1989 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited ByLILJA H, HAESE A, BJÖRK T, FRIEDRICH M, PIIRONEN T, PETTERSSON K, HULAND E and HULAND H (2018) SIGNIFICANCE AND METABOLISM OF COMPLEXED AND NONCOMPLEXED PROSTATE SPECIFIC ANTIGEN FORMS, AND HUMAN GLANDULAR KALLIKREIN 2 IN CLINICALLY LOCALIZED PROSTATE CANCER BEFORE AND AFTER RADICAL PROSTATECTOMYJournal of Urology, VOL. 162, NO. 6, (2029-2035), Online publication date: 1-Dec-1999.BOCHNER B, FIGUEROA A, SKINNER E, LIESKOVSKY G, PETROVICH Z, BOYD S and SKINNER D (2018) SALVAGE RADICAL CYSTOPROSTATECTOMY AND ORTHOTOPIC URINARY DIVERSION FOLLOWING RADIATION FAILUREJournal of Urology, VOL. 160, NO. 1, (29-33), Online publication 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IV. Anti-Androgen Treated PatientsJournal of Urology, VOL. 141, NO. 5, (1088-1090), Online publication date: 1-May-1989. Volume 141Issue 5May 1989Page: 1084-1087 Advertisement Copyright & Permissions© 1989 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Thomas A. Stamey More articles by this author John N. Kabalin More articles by this author Michelle Ferrari More articles by this author Expand All Advertisement Loading ...