Titration of beta-blockers in elderly CHF patients increased median anti-cTnI levels from 0.56 to 0.67 RVU (P<0.001), though levels did not correlate with disease severity.
RCT (n=138)
Double-blind
Randomized
Does titration of beta-blocker therapy affect levels of autoantibodies against cardiac troponin I in elderly patients with congestive heart failure?
Anti-cTnI levels increase following beta-blocker titration in elderly CHF patients but do not correlate with disease severity, suggesting it is not a useful biomarker for heart failure monitoring.
Tasa de eventos absoluta: 0.67% vs 0.56%
valor p: p=<0.001
AIMS: In this randomized, double-blind clinical study, we investigated the relationship between autoantibodies against cardiac troponin I (cTnI) and disease severity in elderly congestive heart failure (CHF) patients before and after titration of beta-blocker therapy. METHODS AND RESULTS: Anti-cTnI, cTnI, and N-terminal pro-brain natriuretic peptide (NT-proBNP) levels in blood from 138 patients (73 +/- 5.6 years, 48% male) with CHF in American Heart Association stages A-C were measured at baseline and after titration of beta-blockers to maximal tolerated dose. Median follow-up period was 85 days. Anti-cTnI was measured using an experimental assay (Abbott Diagnostics) and is expressed as a relative value unit (RVU) in relation to the mean value of a low-level control sample. Anti-cTnI values in CHF patients were also compared with measurements taken in a normal reference population of 300 healthy individuals (50% male). Cardiac troponin I and NT-proBNP levels were measured using routine assays (Architect Abbott Diagnostics and Roche Diagnostics). Median anti-cTnI was 0.53 and 0.56 RVU in healthy and CHF subjects, respectively (P = n.s.), and increased significantly to 0.67 RVU (P < 0.001) after beta-blocker titration. Mean cTnI values were 0.021 microg/L at baseline and fell significantly to 0.0046 microg/L at follow-up (P < 0.001). Median NT-proBNP values were 352 ng/L at baseline and 414 ng/L after titration (P = n.s.). In contrast to NT-proBNP and cTnI, anti-cTnI was not associated with the severity of CHF at baseline or follow-up. CONCLUSION: Levels of anti-cTnI tend to increase in elderly patients with CHF following titration of beta-blocker therapy but do not correlate with disease severity. Anti-cTnI is not a useful biomarker for heart failure diagnosis, prognosis, or monitoring. In contrast, levels of cTnI decreased following therapy and did correlate with disease severity.
Düngen et al. (Mon,) conducted a rct in Congestive heart failure (CHF) (n=138). Beta-blocker therapy vs. Baseline was evaluated on Anti-cTnI levels (p=<0.001). Titration of beta-blockers in elderly CHF patients increased median anti-cTnI levels from 0.56 to 0.67 RVU (P<0.001), though levels did not correlate with disease severity.