Resistance to the action of insulin plays a central role in many important disease states, including diabetes and obesity. Many insights into the mechanism and significance of insulin resistance in these and other disorders have followed upon our expanding knowledge regarding insulin receptors. In this article, we review our current understanding of insulin receptors and their regulation, and we assess the role of insulin receptor pathology in the various syndromes characterized by insulin resistance.
Jeffrey S. Flier (Tue,) studied this question.