Virtue of Prompt Anticoagulant Therapy in Impending Myocardial Infarction: Experiences With 318 Patients During a 10-Year Period

Article1 May 1959VIRTUE OF PROMPT ANTICOAGULANT THERAPY IN IMPENDING MYOCARDIAL INFARCTION: EXPERIENCES WITH 318 PATIENTS DURING A 10-YEAR PERIODE. STERLING NICHOL, M.D., F.A.C.P., WILLIAM C. PHILLIPS, M.D., GUS G. CASTEN, M.D.E. STERLING NICHOL, M.D., F.A.C.P., WILLIAM C. PHILLIPS, M.D., GUS G. CASTEN, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-50-5-1158 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe clinical pattern of coronary atherosclerosis is remarkably variable in different subjects, but observation over a period of years reveals that patients fall into groups delineated by the clinical progression of the disease, as depicted in the diagram below.1. Patients with no previous signs of coronary disease who develop angina pectoris with or without detectable trigger factors such as smoking, dietary excess, gall-bladder disease, hiatal hernia or emotional stress. Some of this group go along well stabilized for years without obvious progression of their coronary disease, with intermittent pain modified by avoiding trigger mechanisms, restriction of activities, the use...Bibliography1. Wearn JT: Thrombosis of the coronary arteries, Am. J. M. Sc. 165: 250, 1923. CrossrefGoogle Scholar2. Kahn MH: Prodromal signs in angina pectoris, Am. J. M. Sc. 194: 42, 1926. Google Scholar3. ParkinsonBedford JDE: Cardiac infarction and coronary thrombosis, Lancet 1: 4, 1926. Google Scholar4. LevineBrown SACL: Coronary thrombosis: its various clinical features, Medicine 8: 245, 1929. CrossrefGoogle Scholar5. Willius FA: Certain factors influencing survival and death in coronary artery disease, Proc. Staff Meet., Mayo Clin. 11: 414, 1936. Google Scholar6. 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Sterling Nichol, M.D., Suite 405—Five Fifty Building, 550 Brickell Avenue, Miami 32, Florida. 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