Enhanced Chemotherapy Efficacy by Sequential Delivery of siRNA and Anticancer Drugs Using PEI‐Grafted Graphene Oxide

Loading and delivery of Bcl-2-targeted short interfering RNA (siRNA) and anticancer drug doxorubicin (DOX) by polyethylenimine (PEI)-conjugated graphene oxide (PEI-GO) is studied. A higher knockdown efficiency of siRNA delivered by PEI-GO than by PEI is achieved. Sequential delivery of siRNA and DOX by the PEI-GO nanocarrier shows a synergistic effect, which leads to significantly improved chemotherapy efficacy. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.