Nitric oxide donors and cardiovascular agents that modulate the NO pathway are reviewed regarding their fundamental chemistry, pharmacology, and cardiovascular mechanisms of action.
This review provides an overview of the chemistry, pharmacology, and cardiovascular mechanisms of nitric oxide donors and agents modulating the NO pathway.
Nitric oxide (NO) mediates multiple physiological and pathophysiological processes in the cardiovascular system. Pharmacological compounds that release NO have been useful tools for evaluating the pivotal role of NO in cardiovascular physiology and therapeutics. These agents constitute two broad classes of compounds, those that release NO or one of its redox congeners spontaneously and those that require enzymatic metabolism to generate NO. In addition, several commonly used cardiovascular drugs exert their beneficial action, in part, by modulating the NO pathway. Here, we review these classes of agents, summarizing their fundamental chemistry and pharmacology, and provide an overview of their cardiovascular mechanisms of action.
Ignarro et al. (Fri,) reported a review. Nitric oxide donors and NO-modulating agents was evaluated. Nitric oxide donors and cardiovascular agents that modulate the NO pathway are reviewed regarding their fundamental chemistry, pharmacology, and cardiovascular mechanisms of action.
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