The cold pressor test and sustained isometric handgrip test increased heart rate and blood pressure but lacked adequate sensitivity for detecting coronary artery disease.
Observational
Are the cold pressor test and sustained isometric handgrip exercise with radionuclide ventriculography useful for detecting coronary artery disease?
Cold pressor and isometric handgrip tests with radionuclide ventriculography are useful for serial evaluation of left ventricular function but should not be used to detect coronary artery disease due to poor sensitivity.
The feasibility of using the cold pressor test and the sustained isometric handgrip test as alternatives to dynamic exercise for stressing the heart was investigated. Serial changes in heart rate, blood pressure, and left ventricular performance induced by these tests were studied by radionuclide ventriculography in patients with coronary artery disease and in normal volunteers. Both tests significantly increased heart rate and blood pressure. The reproducibility of serial evaluation of ejection fraction response to cold pressor and isometric handgrip stresses was satisfactory but the sensitivity for detecting coronary artery disease was not. Both stress tests are valuable interventions for the serial evaluation of left ventricular function by radionuclide ventriculography, but they should not be used to detect coronary artery disease.
Northcote et al. (Wed,) conducted a observational in Coronary artery disease. Cold pressor test and sustained isometric handgrip test was evaluated on Serial changes in heart rate, blood pressure, and left ventricular performance. The cold pressor test and sustained isometric handgrip test increased heart rate and blood pressure but lacked adequate sensitivity for detecting coronary artery disease.