PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
July 21, 1988New England Journal of Medicine302 citations

Open-Heart Surgery in Octogenarians

View Full Paper
LELowell EdmundsLSLarry W. StephensonRERichard N. Edie

Structured PICO

Does open-heart surgery improve survival and functional status in octogenarians with severe cardiac disease?

P
Population
100 consecutive patients aged 80 years or older undergoing open-heart operations (50 with aortic valvular disease, 41 with isolated coronary artery disease, 8 with mitral valvular disease, 1 with dissecting aortic aneurysm; 90 with NYHA Class IV disease).
I
Intervention
Open-heart surgery
O
Outcome
Early death (within 90 days) and long-term survivalhard clinical

Open-heart surgery in octogenarians carries a high early mortality risk but offers acceptable long-term survival and excellent functional recovery for those who survive the perioperative period.

Abstract

One hundred consecutive patients 80 years of age or older consented to and subsequently underwent open-heart operations at our institution between July 1976 and May 1987. Fifty of the patients had aortic valvular disease (28 with coexisting coronary artery disease), and 41 had isolated coronary artery disease. Eight patients had mitral valvular disease, and one had a dissecting aortic aneurysm. Ninety had Class IV disease that was functional, ischemic, or both. The most compelling indications for operation in 85 patients were unstable or postinfarction angina, syncope, acute pulmonary edema, or cardiogenic shock. Twenty-nine patients died soon after operation (within 90 days). New York Heart Association Class IV disease, previous myocardial infarction, cachexia, and emergency operation were preoperative variables associated with early death. Forty-three patients had no complications except for atrial arrhythmias and were discharged from the hospital a mean (+/- SD) of 11.5 +/- 3.7 days after operation. Low cardiac output, acute myocardial infarction, reoperation for bleeding, renal insufficiency, pneumonia, and prolonged endotracheal intubation were the most common serious postoperative complications. Twenty-eight patients who survived postoperative complications were discharged 24.9 +/- 19.6 days after operation. Seventeen patients died 2 to 104 months after discharge from the hospital. Actuarial calculation predicts the survival of 59 percent of patients at three years and 54 percent at five years. Of the 54 patients still alive at this writing, 53 have disease within New York Heart Association and Canadian Cardiovascular Society Classes I or II. For selected octogenarians with unmanageable cardiac symptoms, operation may be an effective therapeutic option.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Edmunds et al. (1988) studied this question.

synapsesocial.com/papers/6a1546a5b2e0231f1582357dhttps://doi.org/10.1056/nejm198807213190302
Ask AI
Helpful
Bookmark
Share
View Full Paper