Why the study?
To generate data-driven phenogroups of cardiac structure and function from echocardiograms in asymptomatic middle-aged adults free of CVD, and evaluate their associations with incident premature CVD.
Does echocardiography-based phenogrouping of suboptimal diastolic or systolic function predict incident premature cardiovascular disease in asymptomatic middle-aged adults?
Population
3361 asymptomatic middle-aged adults free of CVD in the CARDIA cohort
Comparison
Suboptimal systolic or diastolic function phenogroups vs optimal cardiac mechanics
Design
Prospective cohort study
Follow-up
Median 8.9 years
Key result
A suboptimal diastolic function echocardiographic phenogroup was associated with a higher risk of premature CVD compared with optimal cardiac mechanics (adjusted HR 1.95; 95% CI 1.12-3.40).
Authors
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Echocardiographic phenogrouping may refine premature CVD risk stratification in asymptomatic adults; leaves open prospective validation against standard predictors.
Cohort (n=3,361)
Does echocardiography-based phenogrouping of suboptimal diastolic or systolic function predict incident premature cardiovascular disease in asymptomatic middle-aged adults?
Effect estimate: adjusted HR 1.95 (95% CI 1.12, 3.40)
Data-driven clustering of echocardiographic measures identifies distinct patterns of cardiac remodeling, with suboptimal diastolic function predicting the highest risk of premature CVD in asymptomatic middle-aged adults.
Wang et al. (2024) conducted a cohort in asymptomatic middle-aged adults free of CVD (n=3,361). Suboptimal diastolic function phenogroup vs. Optimal cardiac mechanics phenogroup was evaluated on incident premature cardiovascular disease (coronary artery disease, stroke, or heart failure) (adjusted HR 1.95, 95% CI 1.12, 3.40). A suboptimal diastolic function echocardiographic phenogroup was associated with a higher risk of premature CVD compared with optimal cardiac mechanics (adjusted HR 1.95; 95% CI 1.12-3.40).