What does this research mean for the field?

The combined schedule of inactivated and oral poliovirus vaccines used in Denmark achieves high acceptance rates and provides robust population immunity, with over 95% of the population possessing antibodies to poliovirus. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 1, 1984

Vaccination with Inactivated Poliovirus Vaccine and Oral Poliovirus Vaccine in Denmark

PICO estructurado

Población

Children in Denmark

Intervención

Inactivated poliovirus vaccine (IPV) at 5, 6, and 15 months of age, followed by trivalent oral poliovirus vaccine (OPV) at 3, 4, and 5 years of age

Resultado

Vaccine acceptance rate and serum antibody titers to poliovirussurrogate

The sequential IPV and OPV vaccination program in Denmark achieves high acceptance rates and robust population immunity against poliovirus.

Resumen

In Denmark a polio vaccination program including both inactivated poliovirus vaccine (IPV) and oral poliovirus vaccine ( OPV ) has been in use since 1968. Three injections of IPV are given when the children are five, six, and 15 months of age. Subsequently, three vaccinations with trivalent OPV are administered at the age of three, four, and five years. The acceptance rate is high-93%-98%-and greater than 95% of the population has antibodies to poliovirus. The geometric mean titer of serum antibodies is much greater than 10 IU for all three types. The epidemiology of poliomyelitis and the background for the development of the present vaccination schedule are reviewed.

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