Inferior vena cava-inferior atrial ganglionated plexus nerve activity (IVC-IAGPNA) was invariably associated with ventricular rate reduction during atrial fibrillation in ambulatory dogs.
Does inferior vena cava-inferior atrial ganglionated plexus nerve activity (IVC-IAGPNA) control ventricular rate during atrial fibrillation in ambulatory dogs?
In an ambulatory dog model, IVC-IAGPNA is invariably associated with ventricular rate reduction during AF, indicating that the vagal nerve controlling VR during AF may differ from the one controlling sinus rhythm.
Tasa de eventos absoluta: 178% vs 211%
valor p: p=<0.001
BACKGROUND: We hypothesize that inferior vena cava-inferior atrial ganglionated plexus nerve activity (IVC-IAGPNA) is responsible for ventricular rate (VR) control during atrial fibrillation (AF) in ambulatory dogs. METHODS AND RESULTS: We recorded bilateral cervical vagal nerve activity (VNA) and IVC-IAGPNA during baseline sinus rhythm and during pacing-induced sustained AF in 6 ambulatory dogs. Integrated nerve activities and average VR were measured every 10 seconds over 24 hours. Left VNA was associated with VR reduction during AF in 5 dogs (from 211 bpm 95% CI, 186-233 to 178 bpm 95% CI, 145-210; P<0.001) and right VNA in 1 dog (from 208 bpm 95% CI, 197-223 to 181 bpm 95% CI, 163-200; P<0.01). There were good correlations between IVC-IAGPNA and left VNA in the former 5 dogs and between IVC-IAGPNA and right VNA in the last dog. IVC-IAGPNA was associated with VR reduction in all dogs studied. Right VNA was associated with baseline sinus rate reduction from 105 bpm (95% CI, 95-116) to 77 bpm (95% CI, 64-91; P<0.01) in 4 dogs, whereas left VNA was associated with sinus rate reduction from 111 bpm (95% CI, 90-1250) to 81 bpm (95% CI, 67-103; P<0.01) in 2 dogs. CONCLUSIONS: IVC-IAGPNA is invariably associated with VR reduction during AF. In comparison, right or left VNA was associated with VR reduction only when it coactivates with the IVC-IAGPNA. The vagal nerve that controls VR during AF may be different from that which controls sinus rhythm.
Park et al. (Tue,) conducted a other in Pacing-induced sustained atrial fibrillation (n=6). Recording of vagal nerve and IVC-IAGPNA activity vs. Baseline sinus rhythm was evaluated on Ventricular rate reduction during AF associated with left vagal nerve activity (in 5 dogs) (p=<0.001). Inferior vena cava-inferior atrial ganglionated plexus nerve activity (IVC-IAGPNA) was invariably associated with ventricular rate reduction during atrial fibrillation in ambulatory dogs.