Distinct Symptom Occurrence Subgroups Among Patients With Colorectal Cancer: Differences in Social Determinants of Health and Diet Quality

ABSTRACT Colorectal cancer (CRC) is a leading cause of cancer mortality in the United States. Many patients with CRC experience physical and psychological symptoms that diminish quality of life and are shaped by social determinants of health (SDOH) and diet quality. This study aimed to (a) identify distinct symptom occurrence subgroups among patients with CRC, and (b) examine differences in SDOH characteristics and diet quality across these symptom occurrence subgroups. We conducted a secondary analysis of the ColoCare Study dataset from the Huntsman Cancer Institute, including CRC patients 6 months postdiagnosis. Latent class analysis identified subgroups based on the presence of symptoms. Chi‐square tests and ANOVA examined subgroup differences in SDOH and diet quality, measured by the Healthy Eating Index (HEI)‐2020. Logistic regression adjusted for cancer stage, comorbidity status, neoadjuvant or adjuvant therapy. Among 256 patients, three subgroups emerged: low ( n = 84), moderate ( n = 123), and high symptom occurrence ( n = 49). Patients with high symptom occurrence were younger (F = 4.48, p = 0.01), more often Hispanic (χ² = 9.10, p = 0.01), had lower income (χ² = 12.92, p = 0.01), and more frequently received neoadjuvant therapy (χ² = 10.30, p = 0.006). They reported lower total social support (F = 5.60, p = 0.004) and poorer diet quality (F = 9.58, p = 0.0001). After adjustment, high symptom occurrence group had lower odds of adequate income (OR = 0.28, p = 0.0312), social support (OR = 0.886, p = 0.0100), and diet quality (OR = 0.94, p = 0.0156). Distinct CRC symptom profiles highlight the need for personalized dietary interventions and enhanced social support to improve symptom management. Patient or Public Contribution Findings emphasize care strategies that address SDOH to optimize outcomes and quality of life for patients with CRC.