Benefits of daily online plan adaptation with reduced margins in neoadjuvant chemoradiotherapy for esophageal cancer

Background and purpose: Image-guided radiotherapy (IGRT) for esophageal cancer requires large planning target volume (PTV) margins to account for interfraction variations, increasing radiation-associated side-effects. Cone-beam computed tomography-based (CBCT) online adaptive radiotherapy (oART) enables daily contour and plan adaptation, addressing anatomical changes and allowing for reduced PTV margins while ensuring target coverage. This study compared the dose-volume parameters of daily oART to non-adaptive IGRT in patients with esophageal cancer. Material and methods: Ten patients with distal esophageal or gastroesophageal junction cancer who received neoadjuvant chemoradiotherapy (41.4 Gy/23 fractions) were included retrospectively. Daily IGRT CBCTs were used to emulate oART with artificial intelligence (AI)-assisted target and organs-of-interest contouring, manual edits when necessary, and adaptive re-optimization. PTV margins (Anterior-Posterior, Left-Right, Caudal-Cranial) were reduced from 5, 7, 10 mm (IGRT) to 3, 5, 5 mm (oART), respectively. Mean organs-of-interest and fraction-equivalent (FE) dose-volume metrics between delivered and adaptive plans were compared. Results: = 0.002). Conclusion: CBCT-based oART improved dose distribution in esophageal cancer by enabling PTV margin reduction, improved target coverage and superior organs-of-interest sparing. These findings encourage clinical implementation to reduce radiation-associated side-effects.