Dietary nitrate supplementation for 3 days reduced resting systolic blood pressure (115 vs 120 mmHg; P<0.05) and improved VO2 kinetics during treadmill walking in healthy older adults.
RCT (n=12)
Double-blind
crossover
Does short-term dietary nitrate supplementation reduce resting blood pressure and improve physiological and cognitive function in healthy older adults?
Short-term dietary nitrate supplementation reduces resting blood pressure and improves V̇o2 kinetics during walking in healthy older adults, though it does not alter functional capacity or cognitive performance.
Tasa de eventos absoluta: 115% vs 120%
valor p: p=<0.05
Dietary nitrate (NO 3 − ) supplementation has been shown to reduce resting blood pressure and alter the physiological response to exercise in young adults. We investigated whether these effects might also be evident in older adults. In a double-blind, randomized, crossover study, 12 healthy, older (60–70 yr) adults supplemented their diet for 3 days with either nitrate-rich concentrated beetroot juice (BR; 2 × 70 ml/day, ∼9.6 mmol/day NO 3 − ) or a nitrate-depleted beetroot juice placebo (PL; 2 × 70 ml/day, ∼0.01 mmol/day NO 3 − ). Before and after the intervention periods, resting blood pressure and plasma nitrite were measured, and subjects completed a battery of physiological and cognitive tests. Nitrate supplementation significantly increased plasma nitrite and reduced resting systolic (BR: 115 ± 9 vs. PL: 120 ± 6 mmHg; P < 0.05) and diastolic (BR: 70 ± 5 vs. PL: 73 ± 5 mmHg; P < 0.05) blood pressure. Nitrate supplementation resulted in a speeding of the V̇o 2 mean response time (BR: 25 ± 7 vs. PL: 28 ± 7 s; P < 0.05) in the transition from standing rest to treadmill walking, although in contrast to our hypothesis, the O 2 cost of exercise remained unchanged. Functional capacity (6-min walk test), the muscle metabolic response to low-intensity exercise, brain metabolite concentrations, and cognitive function were also not altered. Dietary nitrate supplementation reduced resting blood pressure and improved V̇o 2 kinetics during treadmill walking in healthy older adults but did not improve walking or cognitive performance. These results may have implications for the enhancement of cardiovascular health in older age.
Kelly et al. (Fri,) conducted a rct in Healthy older adults (n=12). Nitrate-rich concentrated beetroot juice vs. Nitrate-depleted beetroot juice placebo was evaluated on Resting systolic blood pressure (p=<0.05). Dietary nitrate supplementation for 3 days reduced resting systolic blood pressure (115 vs 120 mmHg; P<0.05) and improved VO2 kinetics during treadmill walking in healthy older adults.