Individuals with postural orthostatic tachycardia syndrome demonstrated significantly lower median health utility scores (0.63 vs 0.95) compared to an age- and sex-matched normative population.
Observational (n=404)
No
Does postural orthostatic tachycardia syndrome (POTS) reduce health-related quality of life compared to a normative age- and sex-matched population?
POTS is associated with a profound reduction in health-related quality of life across all domains compared to a normative population, with disutility worse than many other chronic health conditions.
Tasa de eventos absoluta: 0.63% vs 0.95%
valor p: p=<0.001
PURPOSE: The effect of postural orthostatic tachycardia syndrome (POTS) on health-related quality of life (HrQoL) remains poorly studied. Here, we sought to compare the HrQoL in individuals with POTS to a normative age-/sex-matched population. METHODS: Participants enrolled in the Australian POTS registry between 5 August 2021 and 30 June 2022 were compared with propensity-matched local normative population data from the South Australian Health Omnibus Survey. The EQ-5D-5L instrument was used to assess HrQoL across the five domains (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression) with global health rating assessed with a visual analog scale (EQ-VAS). A population-based scoring algorithm was applied to the EQ-5D-5L data to calculate utility scores. Hierarchical multiple regression analyses were undertaken to explore predictors of low utility scores. RESULTS: A total of 404 participants (n = 202 POTS; n = 202 normative population; median age 28 years, 90.6% females) were included. Compared with the normative population, the POTS cohort demonstrated significantly higher burden of impairment across all EQ-5D-5L domains (all P < 0.001), lower median EQ-VAS (p < 0.001), and lower utility scores (p < .001). The lower EQ-VAS and utility scores in the POTS cohort were universal in all age groups. Severity of orthostatic intolerance symptoms, female sex, fatigue scores, and comorbid diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome were independent predictors of reduced HrQoL in POTS. The disutility in those with POTS was lower than many chronic health conditions. CONCLUSIONS: This is the first study to demonstrate significant impairment across all subdomains of EQ-5D-5L HrQoL in the POTS cohort as compared with a normative population. TRIAL REGISTRATION: ACTRN12621001034820.
Seeley et al. (Tue,) conducted a observational in Postural orthostatic tachycardia syndrome (POTS) (n=404). Postural orthostatic tachycardia syndrome (POTS) vs. Age- and sex-matched normative population was evaluated on Median health utility score calculated from EQ-5D-5L (p=<0.001). Individuals with postural orthostatic tachycardia syndrome demonstrated significantly lower median health utility scores (0.63 vs 0.95) compared to an age- and sex-matched normative population.