Vulnerability to alcoholism in men: a behavior-genetic perspective.

The psychological and biological characteristics associated with the vulnerability to alcoholism are reviewed. The predisposing features can be accounted for on the basis of deviations in empirically established temperament traits, thereby supporting the viability of a behavior-genetic perspective for elucidating the susceptibility to alcoholism. The temperament perspective also has heuristic value for improving our understanding of the neurobiological mechanisms that link the genetic predisposition to overt behavior. In addition, the temperament approach has ramifications for the prevention and treatment of alcoholism, as well as for clarifying the etiology and classification of certain other psychiatric disorders. The questions of what may be inherited in alcoholism and how this information can be usefully applied to enhance our knowledge of alcoholism etiology, prevention and clinical management are addressed.