Physician/pharmacist collaboration significantly improved blood pressure control at 9 months compared to control (89.1% vs 52.9%, OR 8.9).
RCT (n=179)
Open-label with blinded outcome assessment
Cluster randomized
Sí
Estimación del efecto: OR 8.9 (95% CI 3.8-20.7)
Tasa de eventos absoluta: 89.1% vs 52.9%
valor p: p=<.001
This was a prospective, cluster randomized controlled trial in patients with uncontrolled hypertension aged 21 to 85 years (mean, 61 years). Pharmacists made recommendations to physicians for patients in the intervention clinics (n=101) but not patients in the control clinics (n=78). The mean adjusted difference in systolic blood pressure (BP) between the control and intervention groups was 8.7 mm Hg (95% confidence interval CI, 4.4-12.9), while the difference in diastolic BP was 5.4 mm Hg (CI, 2.8-8.0) at 9 months. The 24-hour BP levels showed similar effects, with a mean systolic BP level that was 8.8 mm Hg lower (CI, 5.0-12.6) and a mean diastolic BP level that was 4.6 mm Hg (CI, 2.4-6.8) lower in the intervention group. BP was controlled in 89.1% of patients in the intervention group and 52.9% in the control group (adjusted odds ratio, 8.9; CI, 3.8-20.7; P<.001). Physician/pharmacist collaboration achieved significantly better mean BP values and overall BP control rates, primarily by intensification of medication therapy and improving patient adherence.
Carter et al. (Tue,) conducted a rct in Uncontrolled hypertension (n=179). Physician/pharmacist collaboration vs. Control (usual care with educational lectures for physicians and written information for patients) was evaluated on Blood pressure control at 9 months (OR 8.9, 95% CI 3.8-20.7, p=<.001). Physician/pharmacist collaboration significantly improved blood pressure control at 9 months compared to control (89.1% vs 52.9%, OR 8.9).
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