The Response to Artificial Selection Due to Autosomal Genes of Large Effect I. Changes in Gene Frequency at an Additive Locus

In this series of papers, it is proposed to examine the theoretical consequences of the segregation of genes of large effect in populations under artificial selection. The problem of assigning selective values to the genotypes at such a locus is discussed in this paper, and the behaviour in large populations of an additive autosomal gene with two alleles is examined in detail.