A Lung Cancer Prevention Score (LCPS) ≥75 was associated with a significantly lower mortality-to-incidence ratio compared to a score <60 (0.45 vs 0.65; p<0.001).
Cross-Sectional (n=40)
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The Lung Cancer Prevention Score provides a validated framework connecting prevention policy to measurable cancer burden across countries.
Tasa de eventos absoluta: 0.45% vs 0.65%
valor p: p=<0.001
10518 Background: Lung cancer is the leading cause of cancer worldwide. Despite advances in tobacco control, national prevention efforts remain fragmented. We developed and validated the Lung Cancer Prevention Score (LCPS), a 0–100 composite linking prevention policy strength with real-world outcomes for global benchmarking and equity tracking. Methods: Two LCPS models were created. Policy LCPS quantified 12 weighted domains: smoke-free laws, TAPS bans, ≥50% pictorial warnings, ≥75% excise tax, plain packaging, legal-age limits, e-cigarette control, LDCT screening, asbestos ban, radon plan, clean-cooking access, and occupational carcinogen controls. Data-Driven LCPS combined age-standardized incidence (ASIR), mortality (ASMR), mortality-to-incidence ratio (MIR), smoking prevalence, GDP, health expenditure, and HDI (normalized 0–1; higher = stronger prevention). Data from GLOBOCAN 2022, WHO GTCR 2023, World Bank, and UNDP HDR 2023 covered 40 countries (G20 + 20 others). Analyses included correlation, regression (adjusted for GDP, HDI), Bland–Altman agreement, and ROC AUC for MIR ≤0.60. Results: Among 32 complete datasets, Policy and Data-Driven LCPS correlated moderately (r = 0.31; 95% CI –0.04–0.60). Discrimination of favorable outcomes (MIR ≤0.60) showed AUC 0.68 vs 0.77. High-policy countries (≥75) had lower smoking (17%) and MIR (0.45) than those 90 % P 1 Yes = 1 Occ carcinogen ctrl P 1.5 Yes = 1 ASIR D 1 Lower = better (1–scaled ASIR) ASMR D 1 Lower = better (1–scaled ASMR) MIR D 1 Lower = better (1–scaled MIR) Smoking prev D 1</ja
Tangella et al. (Wed,) conducted a cross-sectional in Lung cancer (n=40). High-policy Lung Cancer Prevention Score (LCPS ≥75) vs. Low-policy LCPS (<60) was evaluated on Mortality-to-incidence ratio (MIR) (p=<0.001). A Lung Cancer Prevention Score (LCPS) ≥75 was associated with a significantly lower mortality-to-incidence ratio compared to a score <60 (0.45 vs 0.65; p<0.001).