Increased pulse pressure and pulse wave velocity, but not carotid amplification index (OR 1.00; 95% CI 0.99-1.01), were independently associated with atherosclerotic alterations in hypertension.
Cross-Sectional (n=1,087)
Are pulse pressure, aortic pulse wave velocity, and carotid amplification index associated with atherosclerotic alterations in patients with essential hypertension?
In hypertensive patients, pulse pressure and pulse wave velocity are independent markers of cardiovascular risk, whereas central wave reflections (carotid amplification index) are not.
Effect estimate: OR 1.00 (95% CI 0.99-1.01)
BACKGROUND: Pulse pressure (PP) and aortic pulse wave velocity (PWV) are significant markers of cardiovascular risk, but a similar role for central wave reflections has never been investigated. PROCEDURES: To determine the factors influencing PP, PWV, and carotid wave reflections, a cohort of 1087 patients with essential hypertension either treated or untreated was studied cross-sectionally. Atherosclerotic alterations (AA) were defined on the basis of clinical events and PWV evaluated from an automatic device. The carotid amplification index (CAI), a quantitative estimation of the magnitude of central wave reflections, was measured noninvasively from pulse wave analysis using radial and carotid aplanation tonometry. RESULTS: In the overall population, age and mean arterial pressure represented 30.4%, 32.3%, and 5.6% of the variance of, respectively PP, PWV, and CAI. For the latter, body weight and heart rate represented 22.9% of variability. On the basis of logistic regression, AA were associated, in addition to age, plasma creatinine and HDL cholesterol levels, and tobacco consumption to three mechanical factors, increased PP, increased PWV, and low diastolic blood pressure, but not by CAI (adjusted odds ratio: 1.00; 95% confidence intervals: 0.99-1.01). CONCLUSION: In cross-sectional hypertensive populations, PP and PWV, but not CAI, are significantly and independently associated with cardiovascular amplications.
Roland Asmar (2001) conducted a cross-sectional in essential hypertension (n=1,087). Pulse pressure, aortic pulse wave velocity, and carotid amplification index was evaluated on Atherosclerotic alterations (OR 1.00, 95% CI 0.99-1.01). Increased pulse pressure and pulse wave velocity, but not carotid amplification index (OR 1.00; 95% CI 0.99-1.01), were independently associated with atherosclerotic alterations in hypertension.