Does a 20-min infusion of atrial natriuretic factor affect urinary albumin and beta 2-microglobulin excretion in normal male subjects?
A 20-minute infusion of ANF significantly increases urinary albumin excretion in normal men, suggesting it may enhance glomerular permeability to albumin.
The effect of a 20-min infusion of atrial natriuretic factor (ANF) 99-126, 0.4 microgram/kg per min, on both urinary albumin and beta 2-microglobulin excretion was examined in nine normal male subjects during stable water diuresis. ANF caused a rise in urinary albumin in excretion (from 4.19 +/- 0.66 to 13.49 +/- 3.07 ng/min, P less than 0.01) without any significant change in either creatinine clearance of beta 2-microglobulin excretion. These findings suggest that ANF may enhance glomerular permeability to albumin in man.
McMurray et al. (Sat,) studied this question.
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