Parkinson's disease patients exhibited significantly lower 24-hour heart rate variability (ISDNN 42.9 ms vs 53.4 ms, p=0.01) compared to healthy controls, reflecting circadian autonomic derangement.
Cross-Sectional (n=36)
No
Does Parkinson's disease reduce heart rate variability (ISDNN) in patients without cardiovascular comorbidities compared to healthy controls?
Time-domain assessment of HRV using 24-h ambulatory ECG reveals impaired circadian heart rate variability (reduced ISDNN) in patients with mild to moderate Parkinson's disease, reflecting cardiovascular dysautonomia.
Tasa de eventos absoluta: 42.9% vs 53.4%
valor p: p=0.01
BACKGROUND: Heart rate variability (HRV) decreases in Parkinson's disease (PD) and it can be considered a marker for cardiovascular dysautonomia. The purpose of this pilot study is to evaluate long-term time-domain analysis of HRV of PD patients and compare the results with those of matched healthy individuals. METHODS: Idiopathic PD patients without comorbidity impairing HRV, and age-matched healthy individuals were recruited in a pilot study. A long-term time domain analysis of HRV using 24-h ambulatory ECG was performed. RESULTS: Overall, 18 PD patients fulfilling inclusion criteria completed the evaluation (mean age was 55.6 ± 8.8, disease duration: 5.0 ± 4.7). Mean SCOPA-AUT score was 10.1 ± 7.3. Patients were on Hoehn & Yahr stage 1-2 and mean Levodopa Equivalent Dose (LED) was 311 ± 239.9. Mean of the 5-min standard deviation (SD) of R-R intervals distribution (SDNN) for all 5 min segments of the entire recording (ISDNN) was significantly lower in patients compared to controls. ISDNN was significantly different between Parkinson's disease patients and healthy controls. CONCLUSIONS: In our population characterized by mild to moderate disease severity, time-domain assessment of HRV seemed to be a potential tool to characterize cardiovascular dysautonomia. Decrease of ISDNN in PD may reflect an autonomic derangement extending all day and night long.
Arnao et al. (Thu,) conducted a cross-sectional in Parkinson's disease (n=36). Parkinson's disease vs. Healthy controls was evaluated on ISDNN (Mean of the standard deviation of all NN intervals for all 5 min segments of the entire 24-h recording) (p=0.01). Parkinson's disease patients exhibited significantly lower 24-hour heart rate variability (ISDNN 42.9 ms vs 53.4 ms, p=0.01) compared to healthy controls, reflecting circadian autonomic derangement.