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Investigator-initiated trials are prone to inappropriate analysis and interpretation, which may arise from ignorance of statistical methods or selective reporting of results that 'look interesting' or support the academic bias of the investigators. Multiple post-hoc analyses or selective reporting of outcomes can give rise to outcome reporting bias. The results of a clinical trial should be analysed in accordance with a prospectively prespecified plan. (non-author abstract)
Finfer et al. (Sun,) studied this question.
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