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In Vivo Activation of Macrophages but not Natural Killer Cells by Picolinic Acid (Pla) | Synapse

January 1, 1984

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In Vivo Activation of Macrophages but not Natural Killer Cells by Picolinic Acid (Pla)

RRR. RuffmannRecordati (Italy)RWRoy D. WelkerCommunity Hospital TSTohru SaitoKanazawa University

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Resumen

Intraperitoneal injection of PLA into C57BL/6 mice induced high levels of macrophage-mediated cytostatic activity. Maximal cytostatic activity was found 3 days after injection of 100 mg/kg of PLA. In contrast, natural killer cell activity was not affected by PLA. Thus, PLA selectively modulates macrophage activity without influencing NK activity.

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Cite This Study

Ruffmann et al. (Sun,) studied this question.

synapsesocial.com/papers/6a19f0334b45427442eaee95 https://doi.org/https://doi.org/10.3109/08923978409028605

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Control of growth by picolinic acid: Differential response of normal and transformed cells1977 · 69 citations
2Disproportionate accumulation of 18S and 28S ribosomal RNA in cultured normal rat kidney cells treated with picolinic acid or 5-methylnicotinamide1981 · 10 citations
3Selective toxicity induced by picolinic acid in simian virus 40-transformed cells in tissue culture.1977 · 32 citations
4Inhibition of Aconitase by Chelation of Transition Metals Causing Inhibition of Sporulation in Bacillus subtilis1968 · 36 citations
5Analogues of fusaric (5-butylpicolinic) acid as potent inhibitors of dopamine -hydroxylase.1973 · 15 citations