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This study examined the mediating role of negative stress in the relationship between Psychological Capital (PsyCap) and psychological distress indicators among Ecuadorian university students. PsyCap was conceptualized as a higher-order construct composed of hope, self-efficacy, resilience, and optimism. A cross-sectional study was conducted with 1732 university students (55% women; M = 20.44, SD = 2.29) from three Ecuadorian universities using validated self-report measures. Structural equation modeling supported the proposed mediational model and demonstrated an adequate fit to the data, χ2(367) = 1732, p < 0.001, CFI = 0.972, TLI = 0.969, RMSEA = 0.061 (90% CI 0.058, 0.063), and SRMR = 0.041. PsyCap showed a significant negative association with negative stress (β = −0.311, p < 0.001). In turn, negative stress was positively associated with anxiety–depression symptoms (β = 0.785, p < 0.001) and psychological inflexibility (β = 0.774, p < 0.001). Mediation analyses revealed significant indirect effects of PsyCap on anxiety–depression (β = −0.244, p < 0.001) and psychological inflexibility (β = −0.241, p < 0.001) through negative stress. Direct effects remained significant but smaller in magnitude (β = −0.131 and β = −0.107, respectively), supporting a partial mediation model. The model explained 69.7% of the variance in anxiety–depression and 66.3% of the variance in psychological inflexibility. These findings suggest that PsyCap functions primarily as a protective psychological resource through its capacity to reduce maladaptive stress responses, which subsequently influence broader transdiagnostic indicators of psychological distress. The study highlights the relevance of integrating strengths-based approaches and stress-reduction strategies in university mental health interventions. Furthermore, it provides empirical evidence from a Latin American context, contributing to the understanding of mechanisms linking positive psychological resources and mental health among university students.
Quinde et al. (Thu,) studied this question.
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