This piece provides a historical perspective on the evolution of treatments for heart failure with reduced ejection fraction through a timeline of 26 major RCTs.
As we enter a new era of treatment for heart failure with reduced ejection fraction, historical perspective is provided in a timeline (at NEJM.org) of 26 randomized, controlled trials in heart-failure treatment that have been published in the Journal since 1986.
Sacks et al. (Wed,) studied this question.