Dendrimers with a far-red NDI fluorescent core for efficient and traceable gene and RNA delivery

-GPX4 siRNA-FINO2 formulation sensitizes human colon cancer-derived cells to ferroptosis, synergistically annihilating cancer cells compared to treatment with FINO2 alone. The intrinsically far-red fluorescent NDI G3 dendrimer with a dynamic fluorescence response developed for the combinatorial delivery of siRNA and drug molecules offers a generalized framework for designing next-generation far-red fluorescent dendrimers for nucleic acid therapeutics and theranostic applications.