Randomized trial examines the associations between brain aging, cognitive-motor decline, and vascular risk factors, suggesting actionable preventive strategies.
Key Points
This research aims to uncover the relationships between biological brain aging, cognitive and motor functions, and modifiable vascular risks.
Analyzed data from 40,579 individuals from the UK Biobank and Hamburg City Health Study.
Employed partial least squares correlation analysis to identify associations among cognitive/motor scores and MRI-derived brain aging markers.
Conducted mediation analyses to explore how vascular risks impact cognitive and motor decline via biological brain aging.
A dominant latent dimension explained 94.7% of variance between neuroimaging and behavior.
Higher biological brain aging markers correlated with poorer cognitive and motor performance, especially in executive function (HR evident).
Biological brain aging partially mediated the negative effects of several vascular risks on cognitive and motor functions, excluding cholesterol levels.