Five-decade national trends and forecasting of brain tumor mortality among older adults in the United States, 1968–2035.
Why the study?
Contemporary population-level evaluations of long-term malignant brain tumor mortality trajectories in older adults are limited despite therapeutic advances.
Population
311,680 malignant brain tumor-related deaths among US adults aged ≥65 years
Comparison
Mortality trends stratified by age group, sex, race/ethnicity, census region, state, and urban-rural classification
Design
Retrospective population-based time-series and forecasting analysis
Key result
Malignant brain tumor mortality among U.S. adults aged ≥65 years increased steadily from 1968 to 2023 (AAPC 1.90%; 95% CI 1.6-2.2) and is projected to reach an AAMR of 18.06 by 2035.
Authors
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Rising mortality burden in older adults warrants clinical awareness; extends surveillance trends but leaves open etiologic and preventive research.
Observational (n=311,680)
Yes
Malignant brain tumor mortality among older U.S. adults has risen significantly over the past five decades and is projected to remain elevated through 2035, with accelerating trends among women, Black populations, and Southern regions.
Effect estimate: AAPC 1.90% (95% CI 1.6-2.2)
Chouhan et al. (2026) conducted an observational in Malignant brain tumors (n=311,680). Malignant brain tumor mortality among U.S. adults aged ≥65 years increased steadily from 1968 to 2023 (AAPC 1.90%; 95% CI 1.6-2.2) and is projected to reach an AAMR of 18.06 by 2035.