Orthostatic hypotension and nicotine sensitivity in a case of multiple system atrophy.

, on the basis of some 40 published case reports, described a clinical syndrome to which their names have subsequently been attached. The complete syndrome includes ortho- static hypotension, anhidrosis, urinary and faecal incontinence, sexual impotence, Parkinsonian signs, external ocular palsies, amyotrophy, and iris atrophy. A detailed post-mortem examination of one of their cases showed neuronal degeneration at many sites, including the intermediolateral columns of the spinal cord. They did not comment on the relation of this finding to the autonomic features of their patient's disorder.