An elevated triglyceride glucose index independently predicted coronary artery calcification progression, with progression occurring in 37.5% of the highest tertile versus 22.7% of the lowest tertile.
Cohort (n=12,326)
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Does a higher triglyceride glucose (TyG) index predict the progression of coronary artery calcification in asymptomatic adults?
The TyG index is an independent predictor of coronary artery calcification progression, especially in asymptomatic adults without heavy baseline calcification.
Tasa de eventos absoluta: 37.5% vs 22.7%
valor p: p=<0.001
BACKGROUND: Data on the relationship between the triglyceride glucose (TyG) index and coronary artery calcification (CAC) progression is limited. This longitudinal study evaluated the association of TyG index with CAC progression in asymptomatic adults. METHODS: We enrolled 12,326 asymptomatic Korean adults who had at least two CAC evaluations. The TyG index was determined using ln (fasting triglycerides mg/dL × fasting glucose mg/dL/2). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up coronary artery calcium score (CACS) (Δ√transformed CACS). Annualized Δ√transformed CACS was defined as Δ√transformed CACS divided by the inter-scan period. RESULTS: During a mean 3.3 years, the overall incidence of CAC progression was 30.6%. The incidence of CAC progression (group I lowest: 22.7% versus vs. group II: 31.7% vs. group III highest: 37.5%, P < 0.001) and annualized Δ√transformed CACS (group I: 0.46 ± 1.44 vs. group II: 0.71 ± 2.02 vs. group III: 0.87 ± 1.75, P < 0.001) were markedly elevated with increasing TyG index tertiles. Multivariate linear regression analysis showed that TyG index was associated with annualized Δ√transformed CACS (β = 0.066, P = 0.036). In multivariate logistic regression analysis, the TyG index was significantly associated with CAC progression in baseline CACS ≤ 100. CONCLUSION: The TyG index is an independent predictor of CAC progression, especially in adults without heavy baseline CAC.
Won et al. (Mon,) conducted a cohort in Asymptomatic adults (n=12,326). Triglyceride glucose (TyG) index (highest tertile) vs. Lowest TyG index tertile was evaluated on Coronary artery calcification (CAC) progression (p=<0.001). An elevated triglyceride glucose index independently predicted coronary artery calcification progression, with progression occurring in 37.5% of the highest tertile versus 22.7% of the lowest tertile.