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A decade has passed since the cloning of the insulin-responsive glucose transporter, GLUT4. Numerous studies have demonstrated the complex hormonal and metabolic regulation of GLUT4 gene expression in adipose tissue and muscle. Careful dissection of the regulatory elements in the GLUT4promoter has provided insight into the intricate control of this central gene of glucose homeostasis. Genetic manipulation of mice has provided further insight into the role of GLUT4 in carbohydrate and lipid metabolism at the whole body and tissue-specific levels.
Charron et al. (Mon,) studied this question.