March 4, 2021Open Access

The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation

Puntos clave

Los puntos clave no están disponibles para este artículo en este momento.

Resumen

was required for adaptive NK cell responses in a murine cytomegalovirus model, supporting expansion of these cells. Together, we define the TF regulatory circuitry of human NK cells and uncover a critical role for Bcl11b in promoting NK cell differentiation and function.

Leer artículo completoexternamente

Preguntar a la IA

Me gusta

Guardar

Ver artículo completo

Cite This Study

Holmes et al. (Thu,) studied this question.

synapsesocial.com/papers/6a1bb5811567d2fc4d5ed903 https://doi.org/https://doi.org/10.1126/sciimmunol.abc9801

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Expression of cytoplasmic CD3 ε proteins in activated human adult natural killer (NK) cells and CD3 γ, δ, ε complexes in fetal NK cells. Implications for the relationship of NK and T lymphocytes1992 · 144 citations
2Innate lymphoid cells — a proposal for uniform nomenclature2013 · 2,310 citations
3Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles2005 · 56,784 citations
4Human NK Cell Development: One Road or Many?2019 · 145 citations
5Gene Regulatory Programs Conferring Phenotypic Identities to Human NK Cells2018 · 186 citations

Preguntar a la IA

Me gusta

Guardar

Ver artículo completo