Young patients with hypertrophic cardiomyopathy demonstrated significantly increased sympathovagal imbalance and decreased parasympathetic activity compared to healthy controls, with symptomatic patients showing an abnormal systolic blood pressure response.
Observational (n=77)
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Do young patients with hypertrophic cardiomyopathy exhibit abnormal heart rate variability and blood pressure responses to daily life activities compared to healthy volunteers?
Young patients with hypertrophic cardiomyopathy exhibit impaired heart rate variability and abnormal blood pressure responses, which may serve as predictive markers for future cardiac events.
BACKGROUND: Sudden cardiac death commonly occurs in young patients with hypertrophic cardiomyopathy (HCM); however, their heart rate variability (HRV) and blood pressure (BP) response to daily life activities is not well known. METHODS AND RESULTS: HRV and ambulatory BP monitoring were performed in 20 patients (age range: 7-21 years) and 57 age-matched healthy volunteers (age range: 10-22 years). Time domain variables and spectral data were obtained at hourly intervals throughout the day. To determine the BP response to daily life activities, the ratios of the mean BP and pulse pressure in the morning, afternoon, and night to those during sleeping were calculated. The association between the BP level and HRV was also evaluated. The HCM patients showed significantly increased sympathovagal imbalance and decreased parasympathetic activity in the early morning, around noon, and in the early evening. This abnormality was independent of cardiac symptoms. Symptomatic patients showed a significantly lower systolic BP response in the morning, and a higher incidence of dissociation between sympathetic activity and BP response than asymptomatic patients. CONCLUSION: An abnormal BP response in the presence of impaired HRV appears to be predictive for cardiac events in young patients with HCM.
Yanagi et al. (Thu,) conducted a observational in Hypertrophic Cardiomyopathy (n=77). Heart rate variability and ambulatory blood pressure monitoring vs. Age-matched healthy volunteers was evaluated on Heart rate variability (parasympathetic activity and sympathovagal balance) and blood pressure response to daily life activities. Young patients with hypertrophic cardiomyopathy demonstrated significantly increased sympathovagal imbalance and decreased parasympathetic activity compared to healthy controls, with symptomatic patients showing an abnormal systolic blood pressure response.
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