Baseline log urinary albumin excretion rate (RR 2.63; 95% CI 1.65-4.19), HbA1c, retinopathy, and smoking significantly predicted progression to micro- or macroalbuminuria in type 1 diabetes.
Cohort (n=537)
No
What are the risk factors for the development of microalbuminuria and macroalbuminuria in patients with type 1 diabetes?
Baseline urinary albumin excretion, HbA1c, retinopathy, and smoking are significant predictors of progression to diabetic nephropathy in type 1 diabetes.
Estimación del efecto: RR 2.63 (95% CI 1.65-4.19)
OBJECTIVE: To evaluate prospectively putative risk factors for development of microalbuminuria and macroalbuminuria in type 1 diabetes. RESEARCH DESIGN AND METHODS: Prospective observational study of a cohort of type 1 diabetic patients followed in the outpatient clinic at Steno Diabetes Center for or =18 years with type 1 diabetes, with duration of diabetes > or =5 years, with normoalbuminuria (urinary albumin excretion rate 30 mg/24 h in two of three consecutive urine samples). Cox multiple regression analysis using baseline values of putative predictors of progression showed the following significant predictors of progression from normoalbuminuria to microalbuminuria or macroalbuminuria: baseline log urinary albumin excretion rate 2.63 (relative risk; 95% CI 1.65-4.19), HbA(1c) 1.13% (1.04-1.23), presence of any retinopathy 1.90 (1.26-2.88), and smoking 1.61 (1.11-2.33). Sex, duration of diabetes, arterial blood pressure, serum creatinine, height, and social class were not risk factors. CONCLUSIONS: Our study suggests that several potentially modifiable risk factors predict the development of microalbuminuria and macroalbuminuria in type 1 diabetic patients.
Rossing et al. (Wed,) conducted a cohort in Type 1 diabetes (n=537). Risk factor assessment was evaluated on Progression from normoalbuminuria to microalbuminuria or macroalbuminuria (RR 2.63, 95% CI 1.65-4.19). Baseline log urinary albumin excretion rate (RR 2.63; 95% CI 1.65-4.19), HbA1c, retinopathy, and smoking significantly predicted progression to micro- or macroalbuminuria in type 1 diabetes.