Pleural Fluid and Peripheral Blood Lymphocyte Function in Tuberculosis

Brief Reports1 December 1978Pleural Fluid and Peripheral Blood Lymphocyte Function in TuberculosisJERROLD J. ELLNER, M.D.JERROLD J. ELLNER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-89-6-932 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe anergy to tuberculin skin testing, sometimes noted in patients with tuberculous pleurisy, usually has been attributed to preferential sequestration of antigen reactive lymphocytes in the pleural space (1). However, this hypothesis has not been tested. Pleural effusions, in fact, contain an increased proportion of total (2) and immunoglobulin-G Fc receptor-positive (3) thymus-derived lymphocytes relative to peripheral blood, but the significance of these findings is uncertain.We compared the function of peripheral blood and pleural fluid lymphocytes in three patients with culturally documented tuberculous pleurisy. Pleural fluid leukocyte counts ranged from 700 to 7200/µl with 95% to 99% mononuclear cells....References1. STEADBATES WJ: Tuberculosis, in Harrison's Principles of Internal Medicine, 8th ed., edited by THORN GW, ADAMS RD, BRAUNWALD E, ISSELBACHER KJ, PETERSDORF RG. New York, McGraw-Hill, 1977, p. 900 Google Scholar2. PETTERSSONKLOCKARSHELLSTRÖMRISKAWANGEL TMPHA: T and B lymphocytes in pleural effusions. Chest 73:49-51, 1978 CrossrefMedlineGoogle Scholar3. MANCONIFADDACADONICORNAGLIAZACCHEOGRIFONI PMAPDV: Subpopulations of T lymphocytes in human extravascular fluids. Int Arch Allergy Appl Immunol 56:385-390, 1978 CrossrefMedlineGoogle Scholar4. ELLNERDANIEL JT: Immunosuppression by mycobacterial arabinomannan. Clin Exp Immunol, 1978, in press Google Scholar5. ELLNER J: Antigen specific suppressor adherent cells in human tuberculosis (abstract). Clin Res 26:523A, 1978 Google Scholar6. ELLNER J: Suppressor adherent cells in human tuberculosis. J Immunol, in press, 1978. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: University Hospitals Case Western Reserve University Cleveland, Ohio PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byHuman TuberculosisOverview of Clinical TuberculosisTuberculosis and Atypical Mycobacterial InfectionsImmunoregulation in TB: Observations and ImplicationsTUBERCULOSISCellular immunity in tuberculous pleural effusions: evidence of spontaneous lymphocyte proliferation and antigen-specific accelerated responses to purified protein derivative (PPD)RARE INFECTIONS OF THE PLEURAL SPACEClinical Utility of Polymerase Chain Reaction for the Diagnosis of Smear-negative Pleural TuberculosisDiagnosis and Treatment of Tuberculous Pleural Effusion in 2006Sensitivity of Polymerase Chain Reaction for Pleural Tuberculosis according to the Amount of Pleural Effusion SpecimensThe Clinical Utility of Polymerase Chain Reaction for the Diagnosis of Pleural TuberculosisOverview of Clinical TuberculosisCirculating, Mycobacterium tuberculosis -specific lymphocytes from PPD skin test-negative patients with tuberculosis do not secrete interferon-gamma (IFN-γ) and lack the cutaneous lymphocyte antigen skin-selective homing receptorDiagnostic Standards and Classification of Tuberculosis in Adults and ChildrenBovine tuberculosis: immune responses in the peripheral blood and at the site of active diseaseThe T cell receptor subsets of lymphocytes in bronchoalveolar lavage in patients with active pulmonary tuberculosisExamining a paradox in the pathogenesis of human pulmonary tuberculosis: Immune activation and suppression/anergyCase 25-1996Mechanisms of Anergy in TuberculosisRelation of bronchoalveolar lavage T lymphocyte subpopulations to rate of regression of active pulmonary tuberculosis.A CLINICAL VIEW OF TUBERCULOSISLavado broncoalveolar y tuberculosisPleural Fluid Adenosine Deaminase and Lymphocyte Proportion: Clinical Usefulness In the Diagnosis of TuberculosisPathogenesis and Immunology: Basic AspectsImmunology of M. tuberculosis and Other MycobacteriaImmunology of tuberculosisLymphocyte and lymphocyte subset numbers in blood and in bronchoalveolar lavage and pleural fluid in various forms of human pulmonary tuberculosis at presentation and during recovery.Case 23-1992Cooperation between Accessory Cells and T Lymphocytes in Patients with Tuberculous PleurisyCase 49-1990Lymphocyte Proliferation and Gamma-Interferon Production after “in Vitro” Stimulation with PPDLymphocyte subsets in granulomas of human tuberculosis: An in situ immunofluorescence study using monoclonal antibodiesCase 50-1989Adenosine deaminase in body fluids: A useful diagnostic tool in tuberculosisTuberculous pleural effusions: Lymphocyte phenotypes in comparison with other lymphocyte-rich effusionsCase 19-1988Pathogenesis, Pathophysiology, and ImmunologyAnergy and Other Immunologic Perturbances in Mycobacterial InfectionsAdenosine deaminase activity in tuberculous pleural effusions: A diagnostic testAdenosine deaminase activity in the diagnosis of lymphocytic pleural effusions of tuberculous, neoplastic and lymphomatous originT-lymphocytes and Pleural TuberculosisFrequency of Tuberculin-reactive T-lymphocytes in Pleural Fluid and Blood from Patients with Tuberculous PleurisyPathogenic and Protective Interactions in Mycobacterial InfectionsRespiratory Problems in the ElderlyMycobacterial, Fungal, Actinomycotic, and Nocardial Infections of the PleuraPulmonary tuberculosis complicated by haemophagocytic syndrome and rifampicin-induced tubulointerstitial nephritisCase 16-1983Indomethacin-responsive mononuclear cell dysfunction in “atypical” mycobacteriosisPPD-Specific Proliferative Response in Humans: I. Analysis of PPD-Specific Proliferative Cells from Tuberculous Pleurisy Patients and Healthy Controls with Monoclonal Antibodies Specific for Human T SubsetsBCG-induced macrophage suppression in mice: Suppression of specific and nonspecific antibody-medicated and cellular immunologic responsesTuberculosis in the 1980sTHE IMMUNOLOGY OF TUBERCULOSISCutaneous Testing in the Elderly Patient with Tuberculosis 1 December 1978Volume 89, Issue 6Page: 931-932KeywordsAnergyAntigensBloodCellsHematologic testsLymphocytesPleural effusionTuberculin ePublished: 1 December 2008 Issue Published: 1 December 1978 PDF downloadLoading ...