Patients with atrial septal defect had a higher risk of first-time atrial fibrillation after closure compared with a matched general population cohort (adjusted HR 8.2; 95% CI 6.6 to 10.2).
Cohort (n=1,168)
Does atrial septal defect closure prevent atrial fibrillation and stroke in adult patients with atrial septal defect compared to a matched general population?
Adult patients with atrial septal defect continue to have a significantly higher risk of atrial fibrillation and stroke even after defect closure compared to the general population.
Estimación del efecto: HR 8.2 (95% CI 6.6 to 10.2)
Tasa de eventos absoluta: 11% vs 2%
OBJECTIVE: To estimate the risk of atrial fibrillation (AF) and stroke and the impact of closure in patients with atrial septal defect (ASD) compared with a general population cohort. METHODS: All adult Danish patients (>18 years) diagnosed with ASD from 1977 to 2009 (N=1168) were identified through population-based registries. Using Cox regression, we compared ASD patients' risk of AF and stroke with an age-matched and gender-matched comparison cohort. We computed prevalence proportions of anticoagulation and antiarrhythmic medicine use before and after closure and described stroke-related mortality. RESULTS: Median follow-up was 9.6 years (range 1-33 years). Patients with ASD had a higher risk of first-time AF (adjusted HR 8.2; 95% CI 6.6 to 10.2) after closure than the comparison cohort, but with no difference between transcatheter and surgical closure (HR 1.5, 95% CI 0.6 to 3.5). Patients without prevalent AF had a 10-year cumulative incidence of AF of 11% (95% CI 9% to 14%) after closure compared with 2% (95% CI 1.8% to 2.5%) in the comparison cohort. Patients with ASD with prevalent AF continued to use anticoagulation medicine after closure/diagnosis. Patients with ASD had increased risk of stroke without closure (adjusted HR 2.6; 95% CI 1.4 to 3.0) and with closure (adjusted HR 2.0; 95% CI 1.4 to 2.7). Risk of stroke after closure was related to AF (HR adjusted for AF 1.3; 95% CI 0.9 to 1.9). CONCLUSIONS: Patients with ASD had a higher risk of first-time AF after closure than the comparison cohort. There was no effect of closure on the use of AF-related medicine in patients with prevalent AF.
Nyboe et al. (Tue,) conducted a cohort in Atrial septal defect (n=1,168). ASD closure vs. Age-matched and gender-matched general population cohort was evaluated on First-time atrial fibrillation after closure (HR 8.2, 95% CI 6.6 to 10.2). Patients with atrial septal defect had a higher risk of first-time atrial fibrillation after closure compared with a matched general population cohort (adjusted HR 8.2; 95% CI 6.6 to 10.2).