Single-cell sequencing reveals cellular heterogeneity and molecular mechanisms in tendon and enthesis injury repair

Background: Tendon and enthesis injuries represent a significant global health challenge, severely impairing patient mobility and self-care abilities while imposing substantial medical burdens. Main Body: Poor clinical outcomes in tendon healing stem from the complex enthesis, which involves diverse cell types and signaling pathways. Recent advances in single-cell sequencing technologies have revealed detailed cellular diversity and function in tendon and tendon-bone healing. Using multimodal integration, researchers have identified precise subpopulations of tendon and enthesis cells. They have also clarified cell-to-cell crosstalk and mapped differentiation paths during healing. Conclusion: These new findings, guided by emerging methodological advancements. They offer innovative perspectives for developing targeted clinical interventions for tendon and enthesis injury.