Topographic Distribution of Plaques in the Spinal Cord in Multiple Sclerosis

THE PRESENT work is an attempt to define the topographic distribution of plaques in the spinal cord in multiple sclerosis, thus contributing to the solution of the old and important question of the possible relation of vascular territories to the formation of plaques. Ever since Rindfleisch1(1863) first gave an account of the topography and morphology of plaques there has been constant controversy concerning this problem, which has not yet been definitely solved. Its significance has been realized for many years, and it is possible to say as did Rossolimo2(1904) that it is a question of eminent importance to the understanding of the pathogenesis of multiple sclerosis. Prominent German neuropathologists (Pette,31928; Hallervorden,41940) have stated the opinion that no evidence has been given of a relation of vascular territories to the localization of plaques. Hallervorden4stated that plaques are related neither to arterial