Why the study?
Does the presence of a major depressive episode increase the risk of death, dialysis initiation, or hospitalization in outpatients with chronic kidney disease not receiving dialysis?
Population
267 consecutively recruited outpatients with chronic kidney disease at a VA medical center
Comparison
Presence of a current major depressive episode… vs Absence of a current major depressive episode
Design
Cohort, An MDE was diagnosed by blinded personnel
Follow-up
1 year
Key result
A major depressive episode in CKD patients not on dialysis was associated with an increased risk of death, dialysis initiation, or hospitalization (HR 1.86; 95% CI 1.23-2.84).
Authors
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May support depression screening in nondialysis CKD; leaves open whether treatment reduces events.
Cohort (n=267)
Blinded personnel
No
Does the presence of a major depressive episode increase the risk of death, dialysis initiation, or hospitalization in outpatients with chronic kidney disease not receiving dialysis?
Effect estimate: HR 1.86 (95% CI 1.23-2.84)
Absolute Event Rate: 61% vs 44%
p-value: p=.03
In patients with CKD not on dialysis, a major depressive episode is independently associated with an increased risk of death, dialysis initiation, or hospitalization.
S. Susan Hedayati (2010) conducted a cohort in Chronic kidney disease (n=267). Major depressive episode (MDE) vs. No MDE was evaluated on Composite of death, dialysis initiation, or hospitalization (HR 1.86, 95% CI 1.23-2.84, p=.03). A major depressive episode in CKD patients not on dialysis was associated with an increased risk of death, dialysis initiation, or hospitalization (HR 1.86; 95% CI 1.23-2.84).