Among 2541 healthcare workers, 78.83% had protective measles antibody levels, while 21.17% were below the protective threshold, with the highest susceptibility (32-38%) in those aged 39-50 years.
Cross-Sectional (n=2,541)
No
What is the prevalence of protective measles IgG levels among healthcare workers in a Hungarian university clinic?
A significant proportion (21.17%) of healthcare workers in a Hungarian clinic lack protective measles antibodies, highlighting the need for targeted screening and revaccination, particularly in the 39-50 age group.
Objective: Healthcare workers (HCWs) face elevated risk of measles exposure and may facilitate nosocomial spread. Despite early (1969) national vaccine introduction and high (>99%) coverage, sporadic cases and small outbreaks tend to occur in Hungary pointing to possible immunity gaps. We evaluated quantitative measles IgG levels among HCWs in a Hungarian university clinic to assess immunity against measles morbillivirus. Methods: Between July and November 2024, sera from 2541 HCWs were tested by quantitative ELISA. Antibody titres were categorized into four groups, with >200 mIU/mL considered protective immunity. IgG levels were analyzed by age, sex, and vaccination schedules. Results: Overall, 78.83% had protective antibody levels, while 21.17% were below the protective threshold, including 13.81% with IgG <150 mIU/mL. Unvaccinated group (born before 1968) provided the highest antibody titres exceeding vaccinated groups. Significant differences in serum titres detected between individuals received different vaccine regiments by age groups. Newer combinations, such as MMR-II/Priorix, elicited higher antibody levels compared to old combinations. HCWs aged 39-50 years showed the highest (32-38%) susceptibility. Conclusions: A substantial proportion of HCWs have low level of measles antibodies, especially in specific age cohorts. Targeted screening and revaccination are recommended to close immunity gaps and prevent nosocomial transmission.
Timmer et al. (Sat,) conducted a cross-sectional in Measles immunity (n=2,541). Among 2541 healthcare workers, 78.83% had protective measles antibody levels, while 21.17% were below the protective threshold, with the highest susceptibility (32-38%) in those aged 39-50 years.