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June 1, 1987Circulation

The end-systolic pressure-volume relationship in conscious dogs.

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Why the study?

How do changes in afterload, heart rate, volume, autonomic tone, and inotropic state affect the end-systolic pressure-volume relationship (ESPVR) in conscious dogs?

Population

30 conscious dogs

Comparison

Pharmacologic afterload interventions, changes… vs Baseline/control state and across different…

Design

Preclinical

Authors

JSJohn A. SprattGTGeorge S. TysonDGDonald D. Glower

Discussion

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Overview

ESPVR variability from afterload in conscious dogs cautions against single measurements; leaves open autonomic modulation for clinical translation.

Structured PICO

How do changes in afterload, heart rate, volume, autonomic tone, and inotropic state affect the end-systolic pressure-volume relationship (ESPVR) in conscious dogs?

P
Population
30 conscious dogs
I
Intervention
Pharmacologic afterload interventions, changes in heart rate, volume loading, and inotropic state augmentation (calcium or dobutamine) with and without autonomic blockade
C
Comparator
Baseline/control state and across different afterload conditions
O
Outcome
Slopes (Emax) and intercepts (Vd) of ESPVR regression linessurrogate

The end-systolic pressure-volume relationship is valid in conscious dogs but its measurement is limited by significant variability due to afterload changes and autonomic reflexes.

Limitations

  • All estimates of the ESPVR involved large extrapolations to obtain estimates of Vd

Cite This Study

Spratt et al. (1987) studied this question.

synapsesocial.com/papers/6a1de59266b24d664b604992https://doi.org/10.1161/01.cir.75.6.1295
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