Non-Biopsy Diagnosis of ATTR-CM: How Safe Is ‘Non-Invasive’?

Puntos clave

• Evaluate the safety and accuracy of non-invasive diagnostic methods for ATTR-CM compared to biopsy.
• Conducted a randomized trial with a control group using imaging techniques and serum biomarkers.
• Included a diverse population suspected of having ATTR-CM.
• Followed up with participants to assess diagnostic outcomes and safety.
• Non-invasive methods demonstrated a diagnostic accuracy of 85% (95% CI: 75-95), P=0.01.
• Reported adverse events associated with non-invasive methods were minimal, with a 2% event rate.
• Highlighting the potential for non-invasive approaches to reduce the need for biopsy in diagnosing ATTR-CM.