Triple antihypertensive therapy over 3 years reduced blood pressure to 120-135/80-90 mmHg, resolved erectile dysfunction, and reduced left ventricular mass from 233.17 g to 172.8 g.
Case Report (n=1)
Effective blood pressure control with triple therapy and lifestyle modifications can reverse hypertensive cardiac remodeling and improve symptomatic vascular manifestations like erectile dysfunction.
Objective: The authors present a 50-year-old male patient, smoker, without regular medical follow-up, with arterial hypertension since age 12 (without formal clinical diagnosis) and a family history of hypertension in his father, with no premature cardiovascular events. He was admitted to the Emergency Department after a BP of 247/121 mmHg documented during an outpatient visit. The patient was asymptomatic, without headache, visual disturbances, or precordial pain, but reported erectile dysfunction of several years’ duration. Laboratory evaluation showed normal renal function and mildly elevated high-sensitivity troponin T (20 ng/L; reference 210 mmHg). Therapy was intensified to triple therapy with lifestyle counseling including CV risk factor control, smoking cessation, and dietary modification. Results: Over three years, BP gradually improved (SBP 120–135 mmHg, DBP 80–90 mmHg), coinciding with complete resolution of erectile dysfunction. Echocardiographic follow-up demonstrated regression of LVH: after one year, mild hypertrophy (septum 11.8 mm, posterior wall 10.8 mm, mass 159.07 g 80.79 g/m2); after two years, mild hypertrophy persisted with meso-apical hypertrabeculation (septum 12.2 mm, posterior wall 11.9 mm, mass 172.8 g 87.98 g/m2). Conclusions: Hypertension is associated with myocardial remodeling, particularly LVH, often clinically silent but it's a strong marker of CV risk. Adequate BP control can reverse hypertensive cardiac remodeling, reducing long-term CV risk. Additionally, hypertension causes erectile dysfunction, a symptomatic vascular manifestation impacting quality of life. This case highlights that effective BP control can simultaneously reverse asymptomatic target-organ damage and improve patient-centered outcomes.
Sá et al. (Fri,) conducted a case report in Arterial hypertension (n=1). Triple antihypertensive therapy and lifestyle counseling was evaluated on Blood pressure control, resolution of erectile dysfunction, and regression of left ventricular hypertrophy. Triple antihypertensive therapy over 3 years reduced blood pressure to 120-135/80-90 mmHg, resolved erectile dysfunction, and reduced left ventricular mass from 233.17 g to 172.8 g.