Plasma adrenomedullin concentration was independently and positively associated with pulse wave velocity (beta-coefficient 0.11; 95% CI 0.026-0.19; p=0.01).
Cross-Sectional (n=853)
Is plasma adrenomedullin concentration associated with pulse wave velocity in hypertensive patients?
Plasma adrenomedullin concentration is independently associated with pulse wave velocity, suggesting it may serve as a marker of advanced arterial stiffness in hypertensive patients.
Estimación del efecto: beta-coefficient 0.11 (95% CI 0.026-0.19)
valor p: p=0.01
Objective: The aim of the study was to investigate the relationship between pulse wave velocity (PWV) and adrenomedullin (ADM) in hypertensive patients. Design and method: We analyzed plasma ADM concentration in 853 patients. Carotid-femoral PWV was performed using the SphygmoCor XCEL device, AtCor Medical. Spearman correlation analysis and multivariable linear regression were performed to evaluate the association between PWV and ADM. Results: The mean age of the study population was 54.5± 13.5 years. Men constituted 45.8% of the group. Participants suffered from: dyslipidemia (76.8%), diabetes (41.3%), coronary artery disease (11.8%), and cerebrovascular disease (6.2%). The mean value of PWV was 10.2 ± 2.3 m/s. The average blood pressure of the 24-hour ambulatory monitoring was 129 ± 13 mm Hg/77 ± 9 mm Hg. A significant, positive link between PWV and ADM was observed (r = 0.09, p = 0.01). Multivariable regression model, adjusted for sex, age, BMI, diabetes, systolic blood pressure, and smoking status, revealed a positive association between PWV and ADM (beta- coefficient: 0.11, 95% confidence interval: 0.026-0.19, p = 0.01). Conclusions: ADM was independently associated with PWV. These results suggest that plasma AMD concentration may serve as an additional marker of advanced arterial stiffness estimated by PWV.
Dabrowska et al. (Fri,) conducted a cross-sectional in Hypertension (n=853). Plasma adrenomedullin (ADM) concentration was evaluated on Association between pulse wave velocity (PWV) and ADM (beta-coefficient 0.11, 95% CI 0.026-0.19, p=0.01). Plasma adrenomedullin concentration was independently and positively associated with pulse wave velocity (beta-coefficient 0.11; 95% CI 0.026-0.19; p=0.01).