Pemphigus vulgaris (PV) is a rare, chronic, and potentially life-threatening autoimmune vesiculobullous disorder characterized by intraepithelial blister formation involving the skin and mucous membranes. It commonly affects individuals in the fifth to seventh decades of life and is associated with significant morbidity due to fluid and protein loss, metabolic disturbances, and secondary infections if left untreated. This report presents the case of a 50-year-old female patient with severe PV who presented with persistent painful oral ulcerations and recurrent cutaneous blisters over a period of three years. The patient had shown an inadequate clinical response to conventional systemic corticosteroid therapy. Due to the chronicity and severity of the condition, the treatment regimen was modified to include combination immunomodulatory therapy along with systemic corticosteroids, which resulted in marked clinical improvement in both oral and cutaneous lesions. This case highlights the importance of early diagnosis, prompt intervention, and individualized therapeutic strategies in the successful management of pemphigus vulgaris. Timely initiation of appropriate treatment can significantly reduce disease-related morbidity and improve the overall quality of life of affected patients.
Dawrani et al. (Mon,) studied this question.